

💧 Unlock 48 hours of unstoppable hydration — because your skin deserves the VIP treatment.
Cetaphil Deep Hydration 48 Hour Activation Serum is a dermatologist-recommended, fragrance-free serum designed for sensitive and dry skin. Featuring the exclusive HydroSensitive complex, it delivers intense hydration for up to 48 hours while soothing skin sensitivity. Enriched with hyaluronic acid, vitamin E, and B5, this lightweight serum absorbs instantly and layers seamlessly under moisturizers to restore skin’s softness, smoothness, and natural glow.














| ASIN | B0957ZBGBJ |
| Best Sellers Rank | #9,526 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #242 in Facial Serums |
| Customer Reviews | 4.6 4.6 out of 5 stars (1,279) |
| Item model number | 0299.011700 |
| Manufacturer | Galderma |
| Product Dimensions | 1.68 x 1.56 x 5 inches; 2.14 ounces |
| UPC | 302990117004 |
V**H
Super hydrating!!!!!!
When I purchased this item, I'd been dealing with some health issues that left my skin in terrible shape (redness, dull appearance, rough texture, dry, etc). But let me tell you, the first time I used this product, it felt like the heavens opened up, the angels started singing and a light beamed down on me. 🤣 I tested it to see if my face would stay moisturized for 48 hours, and it didn't disappoint. I cleansed my face with a gentle cleanser followed by a hydrating toner. Then I applied this serum. My face didn't feel greasy. A little goes a long way. My face felt so soft and hydrated. And most of all, the redness and dullness had greatly diminished. It has a creamy texture and is fragrance free which I like because I have sensitive skin. But I have to get back to the hydration. My skin feels so plump and smooth and bouncy and shiny. I've been using it for about 6 months and it's definitely a holy grail in my skin care routine. BTW, I'm a 55 year old African American who's currently going through menopause (if that's helpful to anyone). Trust me, if you try this product, you won't be disappointed. And it's very affordable.
M**S
Moisturizer/serum
One of the best moisturizer and serums out there on the market just a little pricey though, but if I was rich, I’d buy it again and again and again
T**H
Great moisturizer
Love this product. Good moisturizer without being greasy.
H**H
Cleans well
No extra residue. Good brand
L**Z
Lightweight texture and no scent
This serum seems a little different from other face serums i have tried, in that the texture at first pump reminds me of lotion more than serum. But once rubbed in, it's very lightweight and absorbs fairly quickly. I use this with the Cetaphil Retinol serum (i'm not sure if i'm supposed to or need to, but so far no bad interactions/ side effects). The pump is easy to use and the serum is not greasy. No detectable scent.
M**N
Good for sensitive skin
Love this, but sometimes it pills on my skin and I don’t know why. Maybe I use too much product?
C**Y
Go to skincare
I love this lotion because it is lightweight and hydrating. There is no fragrance and it really helps with dryness. My husband even used it too. Great value compared to more expensive brands making it my go to skincare.
S**N
My skin is loving it
Gentle and moisturizing. Makes my skin feel so great , not greasy but definitely nourished . Highly recommend Buying it again for vacation
V**Z
Es más una formula cremosa, se absorbe rápido y me gustó mucho para preparar la piel antes del maquillaje. Mi piel es muy seca, con tendencia al eccema y sensible, si bien lo compré para el rostro me ayuda mucho para el eccema en mis manos, no se requiere mucho producto, tiene un olor extraño, pero se quita.
A**N
Tengo rosácea y me salen espinillas quisticas y con este producto me han dejado de salir y me ha bajado la irritación.
R**O
Excelente producto para mí que tengo piel sensible me sirve mucho
Z**M
Good for skin hydration.
Trustpilot
2 weeks ago
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