Gynostemma (Jiaogulan) Capsules Antioxidant: Gynostemma capsules has been found to increase superoxide dismutase (SOD), which is a powerful endogenous cellular antioxidant. Studies have found it increases the activities of macrophages, T lymphocytes and natural killer cells and that it acts as a tumor inhibitor. Adaptogen: Gynostemma is known as an adaptogen, which is an herb reputed to help the body to maintain optimal homeostasis. Its chemical constituents include the triterpenoid saponins gypenosides which are closely structurally related to the ginsenosides which are present in ginseng and ashwagandha. Most research has been done since the 1960s when the Chinese realized that it might be a more cost efficient source of adaptogenic compounds, removing pressure from the ginseng stock. Adaptogenic effects include regulating blood pressure and the immune system, improving stamina and endurance. Gynostemma is also believed to be useful in combination with codonopsis for jet lag and altitude sickness. Blood pressure: The adaptogenic nature of gypenosides have been found to keep blood pressure in a normal range. In vitro studies indicate that jiaogulan stimulates the release of nitric oxide in isolated heart cells; this is one proposed mechanism by which jiaogulan reduces high blood pressure. In a double-blind study, gypenosides administered to those with Grade II hypertension showed 82% effectiveness in reducing hypertension, compared to 46% for ginseng and 93% for indapamide (a hypertension medication). Cardiovascular functions: Animal studies as well as clinical testing on humans suggest that Gynostemma , when combined with other herbs, has beneficial effects on cardiovascular system, increasing heart stroke volume, coronary flow, and cardiac output while reducing the heart rate, without affecting arterial pressure. Cholesterol reduction: Numerous clinical studies in Chinese medical literature have shown that Gynostemma lowers serum cholesterol, triglyce
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