NuSciPure Mannitol Powder (1000 grams (2.2 lb))

Yes, Mannitol does work to treat and keep away chronic UTIs, as well as D-Mannose, and is a lot cheaper, mainly because Mannitol has been used in the food industry for a long time as a sugar substitute, and is readily available in bulk quantities.The original paper that described how and why both D-Mannose and D-Mannitol work was "Effect of Carbohydrates on Adherence of Escherichia coli to Human Urinary Tract Epithelial Cells" published in Infection and Immunity, Nov. 1980, p. 531-537. You can Google it and read it. Basically, most UTIs are caused by E. Coli, and E. Coli cause chronic UTIs that are hard to wipe out with antibiotics by adhering to the epithelial cells of the bladder. But, most E.Coli also readily bind both Mannose and Mannitol and this make them less adherent to the epithelial cells, and the E. Coli can then be washed away by drinking lots of fluids and emptying your bladder frequently.Both Mannose and Mannitol are not absorbed as well as glucose/sucrose/fructose and both are also not metabolized to any extent. So they don't make you gain weight or make your diabetes worse.The bad news is that some UTIs are not caused by E. Coli, and some strains of E. Coli do not bind either Mannose or Mannitol, so it doesn't always work for everybody.Plus, ingesting a lot of sugars into your gut that don't get absorbed into your body leaves these sugars in your gut where the gut bacteria start digesting them, and this may cause loose stools or diarrhea, as well as lots and lots of gas. This does seem to improve with time, though, if you persist and let your gut flora adjust to it.

I first started taking this when I heard it could get rid of bladder infections. IT DOES! You have to take mega high doses of it at first, then taper down every so many hours until only a few doses a day. Can't remember the exact doses and times but you can find it on the web. I ran out of this from a vitamin company (Now) I was buying this from, but found this company carried it in bulk. I have used several other kinds of their bulk suppliments with great results and quite the cost savings. This is as very bit pure as they say it is. It's sweet so it's like swallowing a spoonful of powdered sugar.I was reaching the point ready to hit the walk-in clinics for antibiotics this evening, but I received my order of this stuff this afternoon and within 6 hours of taking my doses, I was able to get to sleep and won't need to get antibiotics in the morning! This is the bomb when it comes to bladder infections. It works by not letting the bad bacteria get attached to the bladder walls, therefore you need to drink lots and take this and it gets eliminated pretty quickly, 3-4 days.I will also be using it as a sugar substitute. I am a happy camper tonight. Female bladder infections are so uncomfortable!

I have kidney stones and it helps flush me out instead of drinking so much sugar all the time.

I'd read recently of a study that found that Mannitol given to fruit flies with PD reversed the PD symptoms from being completely unable to walk to walking normally again. My mother has PD and has gone from taking her meds for it every 6 hours to every 3 hours to get through the day as symptom-free as possible. After doing a little research and finding that they haven't yet determined a "dosage" adequate for the same results in humans, I figured it couldn't hurt to give it a try. And, replacing sugar with something natural when and wherever possible is a good thing. I started replacing the majority of the sugar in her coffee every morning with this. Mannitol is 75% as sweet as sugar, so it takes considerably more to get the right level of sweetness to taste as sugar. What I've done is added about 25% or so of sugar to the Mannitol to reduce the amount needed, make it last a little longer, and get it to where I'm using no more than I was sugar in her coffee.I've been giving this to her every morning now for 2 months and what I'm seeing is an increase in the length of time she can go between her medication doses...gradually getting up to 5 hours between; occasionally longer. I can't help but think that giving this to her is helping to increases the time between medication doses. I'll continue to give this to her daily and monitor her changes. My hope is to get her to between 6 & 8 hours between doses...or longer.

Didn't work as I was hoping

Overall I am very pleased with prime and use it a lot.

Excalty what I wanted

It really helps me being constipated and passing a bowel movement recommend at anytime