---
product_id: 4085453
title: "Research - Methylguard - Dietary Supplement with Folate and B12-180 Vegetarian Capsules"
brand: "thorne"
price: "A$132"
currency: AUD
in_stock: true
reviews_count: 8
category: "Thorne"
url: https://www.desertcart.com.au/products/4085453-research-methylguard-dietary-supplement-with-folate-and-b12-180-vegetarian
store_origin: AU
region: Australia
---

# Enhances brain & nerve function Supports healthy methylation Boosts heart & vascular health Research - Methylguard - Dietary Supplement with Folate and B12-180 Vegetarian Capsules

**Brand:** thorne
**Price:** A$132
**Availability:** ✅ In Stock

## Summary

> 🛡️ Elevate your vitality with the pro-grade methylation edge!

## Quick Answers

- **What is this?** Research - Methylguard - Dietary Supplement with Folate and B12-180 Vegetarian Capsules by thorne
- **How much does it cost?** A$132 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.com.au](https://www.desertcart.com.au/products/4085453-research-methylguard-dietary-supplement-with-folate-and-b12-180-vegetarian)

## Best For

- thorne enthusiasts

## Why This Product

- Trusted thorne brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Long-Lasting Supply:** 180 vegetarian capsules—one daily dose lasts 6 months, maximizing value
- • **Clean & Pure Formula:** Gluten-free, dairy-free, soy-free, and allergen-conscious for mindful wellness
- • **Clinically Trusted Brand:** Chosen by 100+ pro sports teams & top healthcare practitioners in 2023
- • **Comprehensive Wellness Boost:** Targets heart, brain, nerve, and bone health in one potent formula
- • **Precision Methylation Support:** Active methylated folate & B12 for superior absorption and efficacy

## Overview

THORNE Research Methylguard delivers bioactive methylated folate (5-MTHF) and methylcobalamin (B12) in a clean, vegetarian capsule designed to support methylation pathways, heart, brain, nerve, and bone health. Trusted by elite athletes and healthcare pros, this 180-count bottle offers a 6-month supply of premium, allergen-free supplementation to optimize your daily wellness routine.

## Description

Buy THORNE Research - Methylguard - Dietary Supplement with Folate and B12-180 Vegetarian Capsules on desertcart.com ✓ FREE SHIPPING on qualified orders

Review: Quality product that really makes a difference - I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.
Review: So far, so good! - I am not a medical professional. I find this product to be of great quality. It helps me to function on tired mornings, and seems to be working when I take it as part of my morning supplement regimen. I have had no issues with the taste nor the smell. Careful not to overdo it with this and other products that contain redundant ingredients. Always read your labels carefully and cross check for redundancies. Happy with this thus far.

## Features

- Methylation: Support for healthy methylation*
- Multiple Functions: Support for heart, blood vessel, brain, nerve, and bone health*
- Homocysteine: Promotes homocysteine metabolism*
- Active Bs: Contains the active, methylated forms of folate and vitamin B12 (5-MTHF and methylcobalamin)
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B0012FJVA2 |
| Age Range (Description) | Adult |
| Age Range Description | Adult |
| Allergen Information | Dairy Free, Fish Free, Shellfish Free, Soy Free |
| Best Sellers Rank | #17,231 in Health & Household ( See Top 100 in Health & Household ) #487 in Blended Vitamin & Mineral Supplements #1,650 in Diet & Sports Nutrition |
| Brand | THORNE |
| Brand Name | THORNE |
| Container Type | Bottle |
| Customer Reviews | 4.7 out of 5 stars 1,077 Reviews |
| Diet Type | Gluten Free |
| Dosage Form | Capsule |
| Flavor | Unflavored |
| Global Trade Identification Number | 00693749787037 |
| Item Dimensions | 2.89 x 2.89 x 5.22 inches |
| Item Form | Capsule |
| Item Weight | 180 Milligrams |
| Manufacturer | Thorne Research |
| Model Name | e Methyl-Guard - Methylation Support Supplement with Folate and Vitamin B12-180 Capsules |
| Number of Items | 1 |
| Product Benefits | Bone Health |
| Specific Uses For Product | Brain, Heart |
| UPC | 693749787037 885335121343 884733360033 885100656025 881619227596 |
| Unit Count | 180.00 Count |

## Product Details

- **Brand:** THORNE
- **Diet Type:** Gluten Free
- **Flavor:** Unflavored
- **Item Form:** Capsule
- **Product Benefits:** Bone Health

## Images

![Research - Methylguard - Dietary Supplement with Folate and B12-180 Vegetarian Capsules - Image 1](https://m.media-amazon.com/images/I/61Cgh5TOkrL.jpg)

## Questions & Answers

**Q: Is there a scientific study that I can read that will back up these claims?**
A: Absolutely, there are studies!  There are enough that I need to ask you to be more precise in what you want to know.  Which ingredient are you interested in, for what population, and concerning what symptoms?  Your local library may be able to help you access research databases that will allow you to search to your heart's content.  State libraries may be used by any taxpayer, and some medical schools will allow community members a day pass.  Here is a little taste, notice how long this research has been going on: 1) Weisberg, I., Tran, P., Christensen, B., Sibani, S., & Rozen, R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Molecular genetics and metabolism, 64(3), 169-172.2) Grandone, E., Margaglione, M., Colaizzo, D., Cappucci, G., Paladini, D., Martinelli, P., ... & Di Minno, G. (1997). Factor V Leiden, C> T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thrombosis and haemostasis, 77(6), 1052-1054.3) (The title for this one is unfortunate, it is a randomized, controlled clinical study which is the gold standard, and it found the reduced B vitamins to work to alleviate symptoms of major depression as well as homocystine levels. 4) Sontag, J.-M., Wasek, B., Taleski, G., Smith, J., Arning, E., Sontag, E., & Bottiglieri, T. (2014). Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice. Frontiers in Aging Neuroscience, 6, 214. http://doi.org/10.3389/fnagi.2014.00214There is your taste!  There is also research showing lack of/poor sperm count in males with homozygous A1298C variant of MTHFR, higher risks of pre-eclampsia in pregnant women, etc., etc.,  At this point, I'm surprised that routine screening has not yet become a standard of care.  I hope that the variation of research articles here has helped you to understand why a more precise question is needed for a direct answer.  No single study will do it (and never does).  How about 2 decades of research?  :)

**Q: Ingredients?**
A: There seems to be some confusion about the difference between Methyl-Guard and Methyl-Guard PLUS, which costs twice as much as the regular Methyl-Guard listed on this page.Jana B.'s answers above seem to list the ingredients of the plus version, although the amounts appear to match that of the regular version. (?)This version does NOT have Riboflavin (B2) (Riboflavin 5'-Phosphate Sodium). In addition to B2, the plus version also claims to have more of all of the ingredients listed below.I have never purchased MG-Plus but I have a bottle of the regular Methyl-Guard in front of me.Here are the ingredients as listed:3 capsules contain:Vitamin B6 (as Pyridoxal 5'-Phosphate)   20.4 mg   1,020% DVFolate (as L-5 Methyltetrahydrofolate from L-5 Methyltetrahydrofolic Acid, Glucosamine Salt)   1.2 mg   300% DVVitamin B12 (as Methylcobalamin)   1.2 mg   20,000% DVBetaine Anhydrous (Trimethylglycine)   1.8 g   *DV not establishedOther Ingredients:Hypromellose (derived from cellulose) capsuleCalciumCitrateLaurate  (sic)Silicon DioxideSuggested Use: Take 3 capsules two times daily or as recommended by your health-care practitioner. (Personally, I only take 3 a day, not 6)

**Q: This states 180 capsules???**
A: Thorne Research - Methyl-Guard comes in a 180 capsule sized bottle.

**Q: What is the difference between the old label and the new label?**
A: Also some of the amounts are different. 
Old methyl guard:
Three Capsules Contain:
Vitamin B6 (as Pyridoxal 5'-Phosphate) 20.4 mg.
Folate (1.2 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 2 mg DFE
Vitamin B12 (as Methylcobalamin) 1.2 mg.
Betaine Anhydrous (Trimethylglycine) 1.8 g.

New Methyl guard Plus:
Three Capsules Contain:
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg
Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg
Folate (3 mg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE
Vitamin B12 (as Methylcobalamin) 3 mg
Betaine Anhydrous (Trimethylglycine) 1.8 g 

This is from the thorne research website.
I love the old one (helps with depression) but the plus gives me a migraine.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Quality product that really makes a difference
*by A***L on August 4, 2025*

I tell people that this is the first time I have ever felt a vitamin that I took. I have taken other B12 supplements in the past but this is the first one to significantly improve my B12 labs. It may seem expensive but I only take one a day so a bottle lasts me 6 months.

### ⭐⭐⭐⭐⭐ So far, so good!
*by A***. on August 20, 2025*

I am not a medical professional. I find this product to be of great quality. It helps me to function on tired mornings, and seems to be working when I take it as part of my morning supplement regimen. I have had no issues with the taste nor the smell. Careful not to overdo it with this and other products that contain redundant ingredients. Always read your labels carefully and cross check for redundancies. Happy with this thus far.

### ⭐⭐⭐⭐⭐ This is amazing
*by M***G on August 9, 2024*

I never write reviews for supplements. I started taking this because I started using an NAD+ patch. They recommend taking a menthylation supplement. (I'd never even heard of it). I took 3 tablets in the morning before my patch. Within 30 or 45 minutes, I immediately felt great, energetic. I can't even explain it. I hadn't changed anything else. I thought , "no way". I decided to take it the next day as well. Same thing! More energy, clear head, sort of, maybe happier. I can't believe. I've never a supplement do that for me. I have taken everything. I am menopausal and take HT (Evamist and progesterone 200mg). But this is the first thing I have taken to truly have an immediate impact. I can't say you will have the same results. Like I mentioned, I bought for a completely different reason. I'm thrilled with how it makes me feel. It's been 4 days now. It's wonderful.

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*Product available on Desertcart Australia*
*Store origin: AU*
*Last updated: 2026-03-08*